By GEORGE F. & GEORGE KLIEN (eds.) VANDE WOUDE
Meant for simple and scientific researchers, immunologists, virologists and molecular biologists, this publication is a part of a sequence which offers serious overviews on chosen elements of either melanoma learn and the elemental underlying sciences.
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Extra resources for Advances in Cancer Research, Vol. 56
1987). Several transgenic mouse studies have shown that when exogenous c-myc is expressed from tissue-specific enhancers and promoters, malignancies appear in the appropriate tissues, albeit after sufficient time to acquire secondary genetic lesions. Transgenic mice containing the c-my gene driven by the mouse mammary tumor virus promoter-enhancer express c-myc constitutively and inducibly in several tissues (breast, lung, salivary gland, testes, pancreas, spleen). , 1986). These data support the idea that constitutive c-myc expression may provide only the first step in oncogenesis.
1987). However, it has also been reported that human deadenylated PI transcripts are more stable (t112 = 27 min) than deadenylated P2 transcripts ( t 1 / 2 = 17 min), at least after prolonged actinomycin D treatment of HL60 cells (Swartwout and Kinniburgh, 1989). Both deadnylated species are more stable than either PI or P2polyadenylated RNAs ( t 1 / 2 = 12 min) in these studies. As normal untreated fibroblasts or HL60 cells contain only a small amount of c-myc A-RNA (approximately 12% of total c-myc RNA), the potential contribution of these differing stabilities to maintaining ratios of PI : P2 transcripts o r to causing aberrations of these ratios in BL cells is not yet clear.
S. (1985). EMBOJ. 4,667-674. Calame, K. L. (1985). Annu. Rev. Immunol. 3, 159-195. , Geay. H. , Pardee, A. ,and Sonenshein, G. E. (1984). )36,241-247. , and Goldfarb, M. (1987). Mol. Cell. Biol. 7, 3554-3560. 42 CHARLOI’TE A. , Dalla-Favera, R.. , and Groudine, M. Science 238, 12721275. Chung, J.. , Reed, R. , and Leder, P. (1986). Proc. Natl. Acad. Sci. A. 83, 7918-7922. Chung, J . , Sussman, D. , and Leder, P. (1987). ) 51, 100 1- 1008. Cohen, J. H. , Lenoir, G.. , Manel, A. , and Byron. P. A.